Synthesis of Benzofused O- and N-Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C–C Cleavage of Cyclobutanols
Sign Up to like & getrecommendations! Published in 2022 at "Organometallics"
DOI: 10.1021/acs.organomet.2c00015
Abstract: We report a Pd-catalyzed route to heterocycles bearing a tetrasubstituted alkene fragment. Our approach merges the intramolecular carbopalladation of tethered alkynes with an alkylation step produced by the C–C cleavage of cyclobutanol derivatives. An alkenyl-Pd(II)… read more here.
Keywords: cleavage; benzofused heterocycles; synthesis benzofused; cascade carbopalladation ... See more keywords
Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03228
Abstract: Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and an oxa-cyclization. This is a mild, scalable, chemoselective, and… read more here.
Keywords: dioxabicycle scaffolds; synthesis benzofused; strategy; scaffolds via ... See more keywords
Synthesis of Benzofused N-Heterocycles via Rh(III)-Catalyzed Direct Benzannulation with 1,3-Dienes
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.8b03595
Abstract: Benzofused nitrogen heterocycles are prevalent as key core structural motifs in functional molecules. Major syntheses of benzofused nitrogen heterocycles focus on construction of the heterocyclic ring starting from (poly)substituted benzene derivatives. Given that polysubstituted benzene… read more here.
Keywords: direct benzannulation; synthesis benzofused; benzofused heterocycles; catalyzed direct ... See more keywords