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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103016
Abstract: In our pursuit to develop novel non-carbohydrate small molecule Galectin-1 Inhibitors, we have designed a series of 1-benzyl-1H-benzimidazole derivatives and demonstrated their anticancer activity. The compound 6g, 4-(1-benzyl-5-chloro-1H-benzo[d]imidazol-2-yl)-N-(4-hydroxyphenyl) benzamide was found to be most potent…
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Keywords:
mediated anticancer;
benzyl;
benzyl benzimidazoles;
benzimidazoles galectin ... See more keywords
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Published in 2018 at "Journal of Catalysis"
DOI: 10.1016/j.jcat.2018.10.023
Abstract: Abstract With the strategy of in-situ generation of benzyl formates followed by alkoxycarbonylation, a palladium catalyzed carbonylative transformation of benzyl chlorides for the synthesis of benzyl arylacetates and arylacetic acids have been developed. By employing…
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Keywords:
benzyl arylacetates;
benzyl;
benzyl chlorides;
arylacetates arylacetic ... See more keywords
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Published in 2020 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2020.01.018
Abstract: Abstract In this study, benzyl benzoate was successfully synthesized via enzymatic acylation using three immobilized enzymes as biocatalysts. Different acyl donors (benzoic acid and benzoic anhydride), operation regimes (batch, fed-batch), mixing modes (conventional mechanical stirring…
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Keywords:
batch;
benzyl;
synthesis benzyl;
benzyl benzoate ... See more keywords
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Published in 2023 at "Synthesis"
DOI: 10.1055/a-2103-4915
Abstract: Isoindolin-1-one derivatives, which are nitrogen-containing heterocycles, are important key intermediates for many useful organic compounds and natural products. To date, there are no syntheses for these compounds that proceed under mild reaction conditions. Therefore, in…
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Keywords:
reaction;
catalyst free;
water;
isoindolin one ... See more keywords