Enantioselective Synthesis of Biaryl Atropisomers via the Addition of Thiophenols into Aryl-Naphthoquinones.
Sign Up to like & getrecommendations! Published in 2018 at "ACS catalysis"
DOI: 10.1021/acscatal.8b00906
Abstract: We report a cinchona alkaloid catalyzed addition of thiophenol into rapidly interconverting aryl-naphthoquinones, resulting in stable biaryl atropisomers upon reductive methylation. An array of thiophenols and naphthoquinone substrates were evaluated, and we observed selectivities up… read more here.
Keywords: synthesis biaryl; addition; aryl naphthoquinones; biaryl atropisomers ... See more keywords
Enantioselective Ni-Catalyzed Electrochemical Synthesis of Biaryl Atropisomers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b13117
Abstract: A scalable enantioselective nickel-catalyzed electrochemical reductive homocoupling of aryl bromides has been developed, affording enantioenriched axially chiral biaryls in good yield under mild conditions using electricity as a reductant in an undivided cell. Common metal… read more here.
Keywords: synthesis biaryl; enantioselective catalyzed; catalyzed electrochemical; biaryl atropisomers ... See more keywords