Synthesis, bioactivity and mode of action of 5A 5B 6C tricyclic spirolactones as novel antiviral lead compounds.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5115
Abstract: BACKGROUND Plant viral diseases cause tremendous decreases in yield and quality. Natural polycyclic compounds such as those containing carbocycles are often very important lead compounds for drug and pesticide development. Tricyclic spiranoid lactones with 5A… read more here.
Keywords: lead compounds; synthesis bioactivity; tricyclic spirolactones; mode action ... See more keywords
Design, synthesis and bioactivity of a new class of antifungal amino acid-directed phthalide compounds.
Sign Up to like & getrecommendations! Published in 2024 at "Pest management science"
DOI: 10.1002/ps.8028
Abstract: BACKGROUND Peanut southern blight disease, caused by Sclerotium rolfsii, is a destructive soil-borne fungal disease. The current control measures, which mainly employ succinate dehydrogenase inhibitors, are prone to resistance and toxicity to non-target organisms. As… read more here.
Keywords: synthesis bioactivity; phthalide compounds; amino acid; design synthesis ... See more keywords
Synthesis and bioactivity of novel (γ-piperidono)dibenzo-33-aza-14-crown-3 ethers
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02512-7
Abstract: Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity… read more here.
Keywords: bioactivity; novel piperidono; synthesis bioactivity; piperidono dibenzo ... See more keywords
Synthesis and Bioactivity Evaluation of Novel N-Pyridylpyrazolemethanamine Derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-018-8083-4
Abstract: To further explore the structure-activity relationship(SAR) of amide bridge moeity of anthranilic diamides derivatives, a series of N-pyridylpyrazole derivatives was designed, synthesized and their biological activities were evaluated. The chemical structures of novel target compounds… read more here.
Keywords: evaluation novel; novel pyridylpyrazolemethanamine; bioactivity evaluation; pyridylpyrazolemethanamine derivatives ... See more keywords
Design, Synthesis, and Bioactivity of Spiro Derivatives Containing a Pyridine Moiety.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06189
Abstract: We designed and synthesized a series of pyridine spiro derivatives and evaluated their insecticidal and antiviral activities. Some compounds exhibited good insecticidal and antiviral activities. Notably, the E series of compounds displayed good insecticidal activity… read more here.
Keywords: compounds e20; design synthesis; bioactivity spiro; spiro derivatives ... See more keywords
Design, Synthesis, and Bioactivity of 4-Aryl-1H-naphtho[2,3-d]imidazole Derivatives as Potential Fungicides against Phytopathogenic Fungi.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c06030
Abstract: Inspired by marine natural products like kealiinines A-C, a series of 4-aryl-1H-naphtho[2,3-d]imidazole derivatives were designed and synthesized. The results of their antifungal activities showed that among the twenty-eight synthesized compounds, most of them showed excellent… read more here.
Keywords: phytopathogenic fungi; synthesis bioactivity; imidazole derivatives; naphtho imidazole ... See more keywords
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01367
Abstract: In this paper, 26 natural polymyxin components and a new derivative S2 were synthesized, and their differences in efficacy and toxicity have been investigated. Almost all of the synthesized components showed strong activity against both… read more here.
Keywords: investigation individual; components cyclic; toxicity; individual components ... See more keywords
Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03303
Abstract: The first total synthesis of (-)-TAN-2483B, a fungal metabolite possessing a densely functionalized furo[3,4-b]pyran-5-one framework, is achieved in 14 steps from d-mannose. Generation of the 2,6-trans-pyran is by cyclopropane ring expansion followed by α-selective alkynylation.… read more here.
Keywords: total synthesis; synthesis bioactivity; tan 2483b; fungal metabolite ... See more keywords
Synthesis and Bioactivity of the Alanyl Phosphonamidate Stereoisomers Derived from a Butyrophilin Ligand.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00153
Abstract: Aryloxy phosphonamidate derivatives of a butyrophilin 3A1 ligand are stimulants of Vγ9 Vδ2 T cells. However, when bonded to an aryl ester and an amine, the phosphorus is stereogenic, and past compounds were studied as… read more here.
Keywords: phosphonamidate; bioactivity alanyl; ligand; synthesis bioactivity ... See more keywords
Design, Synthesis, and Bioactivity of Novel Bifunctional Small Molecules for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02130
Abstract: The abnormal phosphorylation of the τ-protein is a typical early pathological feature of Alzheimer’s disease (AD). The excessive phosphorylation of the τ-protein in the brain causes the formation of neurofibrillary tangles (NFTs) and increases the… read more here.
Keywords: design synthesis; alzheimer disease; synthesis bioactivity; bioactivity novel ... See more keywords
Synthesis and bioactivity investigation of benzophenone and its derivatives
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d4ra02797c
Abstract: Four benzophenones, three dihydrocoumarins, and two coumarins were synthesised by a 1–3 step reaction, with yields ranging from 6.2 to 35%. Next, we investigated the in vitro antitumour activity of these compounds. Compounds 1, 8,… read more here.
Keywords: bioactivity investigation; benzophenone; synthesis bioactivity; investigation benzophenone ... See more keywords