Synthesis, bioactivity and mode of action of 5A 5B 6C tricyclic spirolactones as novel antiviral lead compounds.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5115
Abstract: BACKGROUND Plant viral diseases cause tremendous decreases in yield and quality. Natural polycyclic compounds such as those containing carbocycles are often very important lead compounds for drug and pesticide development. Tricyclic spiranoid lactones with 5A… read more here.
Keywords: lead compounds; synthesis bioactivity; tricyclic spirolactones; mode action ... See more keywords
Synthesis and bioactivity of novel (γ-piperidono)dibenzo-33-aza-14-crown-3 ethers
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02512-7
Abstract: Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity… read more here.
Keywords: bioactivity; novel piperidono; synthesis bioactivity; piperidono dibenzo ... See more keywords
Synthesis and Bioactivity Evaluation of Novel N-Pyridylpyrazolemethanamine Derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-018-8083-4
Abstract: To further explore the structure-activity relationship(SAR) of amide bridge moeity of anthranilic diamides derivatives, a series of N-pyridylpyrazole derivatives was designed, synthesized and their biological activities were evaluated. The chemical structures of novel target compounds… read more here.
Keywords: evaluation novel; novel pyridylpyrazolemethanamine; bioactivity evaluation; pyridylpyrazolemethanamine derivatives ... See more keywords
Design, Synthesis, and Bioactivity of Spiro Derivatives Containing a Pyridine Moiety.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06189
Abstract: We designed and synthesized a series of pyridine spiro derivatives and evaluated their insecticidal and antiviral activities. Some compounds exhibited good insecticidal and antiviral activities. Notably, the E series of compounds displayed good insecticidal activity… read more here.
Keywords: compounds e20; design synthesis; bioactivity spiro; spiro derivatives ... See more keywords
Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01367
Abstract: In this paper, 26 natural polymyxin components and a new derivative S2 were synthesized, and their differences in efficacy and toxicity have been investigated. Almost all of the synthesized components showed strong activity against both… read more here.
Keywords: investigation individual; components cyclic; toxicity; individual components ... See more keywords
Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03303
Abstract: The first total synthesis of (-)-TAN-2483B, a fungal metabolite possessing a densely functionalized furo[3,4-b]pyran-5-one framework, is achieved in 14 steps from d-mannose. Generation of the 2,6-trans-pyran is by cyclopropane ring expansion followed by α-selective alkynylation.… read more here.
Keywords: total synthesis; synthesis bioactivity; tan 2483b; fungal metabolite ... See more keywords
Synthesis and Bioactivity of the Alanyl Phosphonamidate Stereoisomers Derived from a Butyrophilin Ligand.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00153
Abstract: Aryloxy phosphonamidate derivatives of a butyrophilin 3A1 ligand are stimulants of Vγ9 Vδ2 T cells. However, when bonded to an aryl ester and an amine, the phosphorus is stereogenic, and past compounds were studied as… read more here.
Keywords: phosphonamidate; bioactivity alanyl; ligand; synthesis bioactivity ... See more keywords
Design, Synthesis, and Bioactivity of Novel Bifunctional Small Molecules for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02130
Abstract: The abnormal phosphorylation of the τ-protein is a typical early pathological feature of Alzheimer’s disease (AD). The excessive phosphorylation of the τ-protein in the brain causes the formation of neurofibrillary tangles (NFTs) and increases the… read more here.
Keywords: design synthesis; alzheimer disease; synthesis bioactivity; bioactivity novel ... See more keywords
2,5-Diketopiperazines: A review of source, synthesis, bioactivity, structure, and MS fragmentation.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220801143650
Abstract: BACKGROUND 2,5-Diketopiperazines (DKPs), also called cyclic dipeptides, are the simplest peptide derivatives in nature that are formed by condensation of two amino acids. They are an important category of bioactive substances with various structures. OBJECTIVE… read more here.
Keywords: diketopiperazines review; source synthesis; fragmentation; dkps ... See more keywords
Synthesis, bioactivity, and molecular docking of novel arylpiperazine derivatives as potential AR antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.947065
Abstract: Prostate cancer is one of the malignant tumors and the second most common malignant tumor in men. Clinically used androgen receptor (AR)–targeted drugs can antagonize androgen and inhibit tumor growth, but these drugs can cause… read more here.
Keywords: molecular docking; arylpiperazine derivatives; novel arylpiperazine; bioactivity molecular ... See more keywords
Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054691
Abstract: Pesticides play an important role in crop disease and pest control. However, their irrational use leads to the emergence of drug resistance. Therefore, it is necessary to search for new pesticide-lead compounds with new structures.… read more here.
Keywords: design synthesis; sulfonate; activity; synthesis bioactivity ... See more keywords