Synthesis and bioevaluation of α,α’-bis(1H-1,2,3-triazol-5-ylmethylene) ketones
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DOI: 10.1007/s11696-019-00908-5
Abstract: Abstract Curcumin is an active component of turmeric that has poor solubility, stability and bioavailability. The monocarbonyl curcumin analogues were modified from curcumin to achieve more stable and active compounds as compared to curcumin. Therefore,… read more here.
Keywords: bis triazol; antioxidant activities; ylmethylene ketones; triazol ylmethylene ... See more keywords
Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation.
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DOI: 10.1021/acsmedchemlett.3c00461
Abstract: Cannabidiol (CBD 1) is a nonpsychotic cannabinoid-based drug approved by the U.S. FDA for treating refractory epilepsy, namely, Lennox-Gastaut and Dravet syndrome. However, its low aqueous solubility and oral bioavailability are compensated by administering high… read more here.
Keywords: synthesis bioevaluation; cannabidiol based; cbd based; based prodrugs ... See more keywords
Synthesis and bioevaluation of water-soluble β-cyclodextrin–diterpene acid conjugates
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DOI: 10.1080/14786419.2024.2347449
Abstract: Abstract A series of β-cyclodextrin (β-CD)-conjugates were prepared by combining three abietane-type diterpene acids with two azide-functionalized β-CDs via click chemistry, and the antiviral activity against wild-type and omicron SARS–CoV-2 spike pseudovirus as well as… read more here.
Keywords: synthesis bioevaluation; diterpene acid; bioevaluation water; cyclodextrin ... See more keywords