Diastereodivergent synthesis of bispirooxindoles via asymmetric Friedel-Crafts/aldol cascade reaction: co-catalyst effects on diastereoselective outcomes.
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DOI: 10.1039/c7cc09489b
Abstract: A combination of metal- and organo-catalysts sequentially catalyzing the Friedel-Crafts/aldol tandem reaction between 3-pyrrolyl-oxindoles and isatin-derived β,γ-unsaturated α-ketoesters has been reported, which leads to two types of diastereomeric enantio-enriched bispirooxindoles with three quaternary stereocentres and… read more here.
Keywords: synthesis bispirooxindoles; diastereodivergent synthesis; crafts aldol; bispirooxindoles via ... See more keywords