The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study
Sign Up to like & getrecommendations! Published in 2019 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.07.003
Abstract: Background Elevated striatal dopamine synthesis capacity has been implicated in the etiology and antipsychotic response in psychotic illness. The effects of antipsychotic medication on dopamine synthesis capacity are poorly understood, and no prospective studies have… read more here.
Keywords: synthesis capacity; treatment; dopamine synthesis;
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0740-6
Abstract: Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunction leading to disinhibition… read more here.
Keywords: sub chronic; synthesis capacity; ketamine; dopamine ... See more keywords
Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhab379
Abstract: Aging is associated with declines in multiple components of the dopamine system including loss of dopamine-producing neurons, atrophy of the dopamine system's cortical targets, and reductions in the density of dopamine receptors. Countering these patterns,… read more here.
Keywords: synthesis capacity; mechanism cognitive; elevated dopamine; dopamine synthesis ... See more keywords
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]‐DOPA PET study
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy242
Abstract: Abstract Whilst the role of the Disrupted‐in‐Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterization of its function lends it credibility as a candidate. A key aspect of this… read more here.
Keywords: synthesis capacity; dopamine synthesis; disc1; synthesis ... See more keywords
O3.5. TESTING THE DOPAMINE HYPOTHESIS OF PSYCHOSIS USING POSITRON EMISSION TOMOGRAPHIC IMAGING IN FIRST EPISODE BIPOLAR AFFECTIVE DISORDER AND SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby015.203
Abstract: Abstract Background The dopamine hypothesis of psychosis suggests that dopamine abnormalities are present in psychotic illness, irrespective of diagnostic class. Meta-analyses of Positron Emission Tomography (PET) studies of the dopamine system have shown elevated dopamine… read more here.
Keywords: schizophrenia; synthesis capacity; positron emission; dopamine synthesis ... See more keywords
Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.83161
Abstract: Individual differences in striatal dopamine synthesis capacity have been associated with working memory capacity, trait impulsivity and spontaneous eye-blink rate (sEBR), as measured with readily available and easily administered, ‘off-the-shelf’ tests. Such findings have raised… read more here.
Keywords: dopamine synthesis; synthesis capacity; working memory; striatal dopamine ... See more keywords