Organocatalytic Synthesis of Chiral Halogenated Compounds.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical record"
DOI: 10.1002/tcr.202300061
Abstract: This account summarizes our recent efforts in the enantioselective organocatalytic synthesis of chiral halogenated compounds. The enantioselective α-halogenation of aldehydes, decarboxylative chlorination of β-keto acids, and enantioselective C-C bond formation at the trifluoromethylated prochiral carbon… read more here.
Keywords: organocatalytic synthesis; chiral halogenated; synthesis chiral; halogenated compounds ... See more keywords
Synthesis of chiral α-carbonyl-δ-nitro-ketenedithioacetals via l-proline-catalyzed Michael addition reaction
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-017-3025-1
Abstract: Regioselective synthesis of 1,1-bis(methylthio)-6-nitro-5-arylhex-1-en-3-one has been achieved from α-alkenoylketene dithioacetals with nitromethane using l-proline catalyst via Michael addition. The synthesized compounds 3a–j were well characterised by NMR and mass spectral techniques. One of the structures… read more here.
Keywords: nitro ketenedithioacetals; addition; synthesis chiral; michael addition ... See more keywords
In situ removal of inhibitory products with ion exchange resins for enhanced synthesis of chiral amines using ω-transaminase
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2020.107718
Abstract: Abstract ω-Transaminase (ω-TA) serves as an attractive biocatalyst for the asymmetric synthesis of chiral amines from prochiral ketones. However, the ω-TA reactions suffer from exceedingly unfavorable equilibrium and severe product inhibitions. Most reaction engineering strategies… read more here.
Keywords: synthesis chiral; removal inhibitory; inhibitory products; chiral amines ... See more keywords
Serendipitous one-pot synthesis of chiral dienes from pyranosidic 2,4-bistriflates.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate research"
DOI: 10.1016/j.carres.2021.108351
Abstract: Attempted nucleophilic displacements of l-rhamnosyl 2,4-bistriflates led to serendipitous formation of a chiral diene via competing cascade eliminations. The reaction also followed the same pathway with d-rhamnosyl and d-mannosyl 2,4-bistriflates substrates providing access to dienes… read more here.
Keywords: synthesis chiral; pot synthesis; serendipitous one; dienes pyranosidic ... See more keywords
Synthesis of chiral polyurethanes of cinchona alkaloids for the enantioselective synthesis in asymmetric catalysis
Sign Up to like & getrecommendations! Published in 2019 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2018.09.010
Abstract: Abstract Chiral polyurethanes of cinchona alkaloid were synthesized via repetitive Mizoroki-Heck (MH) coupling reaction. The Pd-catalyzed polycondensation of cinchona urethane dimers and aromatic diiodides afforded the chiral polyurethanes. The chiral polyurethane bearing free OH group… read more here.
Keywords: synthesis; cinchona alkaloids; chiral polyurethanes; synthesis chiral ... See more keywords
Enantioselective [4+2] Annulation to the Concise Synthesis of Chiral Dihydrocarbazoles
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.100840
Abstract: Summary A highly efficient phosphine-catalyzed enantioselective [4 + 2] annulation of allenoates with 3-nitroindoles or 3-nitrobenzothiophenes has been developed. The protocol represents a unique dearomatization–aromatization process to access functionalized dihydrocarbazoles or dihydrodibenzothiophenes with high optical… read more here.
Keywords: annulation; concise synthesis; synthesis chiral; enantioselective annulation ... See more keywords
Significantly enhancing the biocatalytic synthesis of chiral alcohols by semi-rationally engineering an anti-Prelog carbonyl reductase from Acetobacter sp. CCTCC M209061
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2019.110613
Abstract: Abstract Chiral alcohols and their derivatives are vital building blocks to synthesize pharmaceutical drugs and high-valued chemicals. Wild-type carbonyl reductase AcCR from Acetobacter sp. has ideal enantioselectivity toward 11 prochiral substrates (e.e.>99%) but poor activity.… read more here.
Keywords: synthesis chiral; acetobacter; carbonyl reductase; chiral alcohols ... See more keywords
Synthesis of chiral γ-lactones via a RuPHOX-Ru catalyzed asymmetric hydrogenation of aroylacrylic acids
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.05.036
Abstract: Abstract An asymmetric hydrogenation of aroylacrylic acids catalyzed by RuPHOX-Ru catalyst has been developed, affording the corresponding chiral γ-lactones in high yields and with up to 93% ee. The methodology has the advantage of utilizing… read more here.
Keywords: aroylacrylic acids; asymmetric hydrogenation; hydrogenation aroylacrylic; synthesis chiral ... See more keywords
Reductive amination of ketones with ammonium catalyzed by a newly identified Brevibacterium epidermidis strain for the synthesis of (S)-chiral amines
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Catalysis"
DOI: 10.1016/s1872-2067(18)63108-0
Abstract: Abstract The asymmetric reductive amination of achiral ketones with ammonia is a particularly attractive reaction for the synthesis of chiral amines. Although several engineered amine dehydrogenases have been developed by protein engineering for the asymmetric… read more here.
Keywords: synthesis chiral; chiral amines; amination ketones; reductive amination ... See more keywords
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.1c00496
Abstract: Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the past decade, significant advances have been made with respect to the enantioselective synthesis… read more here.
Keywords: synthesis chiral; chiral amines; asymmetric hydrogenation; recent advances ... See more keywords
Synthesis of Chiral Au Nanocrystals with Precise Homochiral Facets for Enantioselective Surface Chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00094
Abstract: Metal surfaces with intrinsic chirality play an irreplaceable role in many significant enantioselective chemical processes such as enantioselective catalysis, sensing, and separation. Nonetheless, current methods for the precise preparation of such chiral surfaces suffer with… read more here.
Keywords: chemistry; homochiral facets; synthesis chiral; surface ... See more keywords