Enantioselective synthesis of (R)-Cinacalcet via cobalt-catalysed asymmetric Negishi cross-coupling.
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DOI: 10.1002/chir.23085
Abstract: A novel enantioselective synthesis of (R)-cinacalcet with 99% enantiomeric excesses (ee) has been achieved. The main strategies of the approach include a gram-scale cobalt-catalysed asymmetric cross-coupling of racemic ester with arylzinc reagent, Hoffman-type rearrangement of… read more here.
Keywords: catalysed asymmetric; cobalt catalysed; synthesis cinacalcet; cross coupling ... See more keywords