Formal Synthesis of (-)-Codeine by Application of Temporary Thio Derivatization.
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DOI: 10.1021/acs.orglett.7b03972
Abstract: Desymmetrization of a p-quinone monoacetal by organocatalytic sulfa-Michael addition provided rapid access to a C-ring building block for a formal synthesis of (-)-codeine. By means of a diastereoselective 1,2-addition for A/C-ring union, an intramolecular nitrone… read more here.
Keywords: codeine; formal synthesis; codeine application; synthesis codeine ... See more keywords