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Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10086-2
Abstract: Abstract In this study, we applied a direct condensation between 3-acetyl-4-hydroxy-2 H -chromen-2-one and different amines (anilines and benzyl amines) in order to synthesize some coumarin-based imines/enamines ( 3a – o ) as cytotoxic agents.…
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Keywords:
imines enamines;
study cytotoxicity;
computational study;
study ... See more keywords
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Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2017.08.005
Abstract: Abstract Two series of new benzodiazepines were synthesized and the target compounds (E1-10 and G1-10) were evaluated for antianxiety and skeletal muscle relaxant activity as CNS agents in albino mice. The chemical structures of the…
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Keywords:
new benzodiazepines;
synthesis computational;
cns agents;
design synthesis ... See more keywords
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Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104467
Abstract: Donor-Acceptor type BODIPYs with strong absorption and fluorescence in the red region (550-800 nm) are reported. The aromatic groups like N-butylcarbazole/ N-butylphenothiazine/ benzothiadiazole were attached to the C-8 position of the BODIPY core with furan or…
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Keywords:
red emitters;
emitters synthesis;
bodipy based;
synthesis computational ... See more keywords
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Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.06.048
Abstract: Abstract A series of nicotinamide derivatives were designed and studied in silico molecular docking predictions against inflammatory responsible enzymes (cyclooxygenase-1(1PGG) and cyclooxygenase-2 (4-COX)). The well-predicted compounds were synthesized, characterized by the spectroscopic techniques namely, Proton…
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Keywords:
predictions selective;
nicotinamide derivatives;
synthesis computational;
vitro biological ... See more keywords
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Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2016.12.032
Abstract: Abstract Synthesis of three [4]heli-viologens and their helical precursors, and two “pseudo-[4]helicenes” and their alkylated derivatives, which have potential device and catalysis applications, are reported. Their structures and racemization barriers have been explored with the…
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Keywords:
computational photophysical;
photophysical characterization;
helicenes pseudo;
pseudo helicenes ... See more keywords
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Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2036241
Abstract: Abstract The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure of Mycobacterium tuberculosis…
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Keywords:
design synthesis;
development;
synthesis computational;
benzimidazole derivatives ... See more keywords
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Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.2021898
Abstract: Abstract Topoisomerase (IIB) inhibitors have been involved in the therapies of tumour progression and have become a major focus for the development of anticancer agents. New three-component hybridised ligands, 1,4-disubstituted-1,2,3-triazoles (8–17), were synthesised via a…
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Keywords:
cell;
computational study;
topoisomerase iib;
acridinyl ... See more keywords
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Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13090229
Abstract: Herein we report the design, synthesis, computational, and experimental evaluation of the antimicrobial activity of fourteen new 3-amino-5-(indol-3-yl) methylene-4-oxo-2-thioxothiazolidine derivatives. The structures were designed, and their antimicrobial activity and toxicity were predicted in silico. All…
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Keywords:
methylene oxo;
indol methylene;
amino indol;
synthesis computational ... See more keywords
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Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14010033
Abstract: Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report…
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Keywords:
green design;
computational analyses;
synthesis computational;
synthesis ... See more keywords