Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D3-Selective Antagonists
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DOI: 10.3390/ijms24010432
Abstract: Previous studies have confirmed that the binding of D3 receptor antagonists is competitively inhibited by endogenous dopamine despite excellent binding affinity for D3 receptors. This result urges the development of an alternative scaffold that is… read more here.
Keywords: synthesis conformationally; design synthesis; flexible scaffold; receptor ... See more keywords