Microwave assisted synthesis of coumarin-purine derivatives: An approach to in vitro anti-oxidant, DNA cleavage, crystal structure, DFT studies and Hirshfeld surface analysis
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e01131
Abstract: An easy and efficient microwave-assisted protocol has been developed for the synthesis of coumarin-purine hybrids (3a-3j). The newly constructed 1,3-dimethyl-7-((substituted)-2-oxo-2H-chromen-4-yl)methyl)-1H-purine-2,6(3H,7H)-dione derivatives were evaluated for their in vitro antioxidant activity by DPPH free radical-scavenging ability assay… read more here.
Keywords: synthesis coumarin; coumarin; microwave assisted; structure ... See more keywords
Green approach for the synthesis of 4-coumarin-4H-pyrans from 4-formylcoumarins and their antibacterial study
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DOI: 10.1080/00397911.2017.1336557
Abstract: ABSTRACT A series of 4H-pyranocoumarin derivatives have been successfully synthesized under eco-friendly condition using triethylamine as a catalyst in short reaction time with excellent yield at room temperature. All the synthesized compounds were characterized by… read more here.
Keywords: synthesis coumarin; green approach; coumarin pyrans; formylcoumarins antibacterial ... See more keywords
An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents
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DOI: 10.3390/molecules27051604
Abstract: Coumarin is an important six-membered aromatic heterocyclic pharmacophore, widely distributed in natural products and synthetic molecules. The versatile and unique features of coumarin nucleus, in combination with privileged sulfonamide moiety, have enhanced the broad spectrum… read more here.
Keywords: coumarin sulfonamide; coumarin sulfonamides; chemistry; coumarin ... See more keywords
Synthesis of Coumarin Derivatives: A New Class of Coumarin-Based G Protein-Coupled Receptor Activators and Inhibitors
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DOI: 10.3390/polym14102021
Abstract: To expand the range of daphnetin-based inhibitors/activators used for targeting G protein-coupled receptors (GPCRs) in disease treatment, twenty-five coumarin derivatives 1–25, including 7,8-dihydroxycoumarin and 7-hydroxycoumarin derivatives with various substitution patterns/groups at C3-/4- positions, were synthesized… read more here.
Keywords: coumarin derivatives; protein coupled; synthesis coumarin; activators inhibitors ... See more keywords