Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2‐b]pyrazole‐7‐carboxamides
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DOI: 10.1002/ardp.201800062
Abstract: The synthesis and in vitro cytotoxic characteristics of new imidazo[1,2‐b]pyrazole‐7‐carboxamides were investigated. Following a hit‐to‐lead optimization exploiting 2D and 3D cultures of MCF‐7 human breast, 4T1 mammary gland, and HL‐60 human promyelocytic leukemia cancer cell… read more here.
Keywords: pyrazole carboxamides; cytotoxic characterization; imidazo pyrazole; sar ... See more keywords
Synthesis and cytotoxic evaluation of malachite green derived oleanolic and ursolic acid piperazineamides
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DOI: 10.1007/s00044-020-02536-1
Abstract: The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid with meta or para substituted carboxylated malachite green analogs gave conjugates 10 , 11 , 15 , and 16 that were cytotoxic for… read more here.
Keywords: ursolic acid; malachite green; cytotoxic evaluation; synthesis cytotoxic ... See more keywords
Synthesis and cytotoxic activity of isocembrol and its hydroxy derivatives
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DOI: 10.1007/s11172-020-2981-6
Abstract: The synthesis of 2- and 3-hydroxy derivatives of isocembrol was accomplished by the epoxidation of isocembrol with tert-butyl hydroperoxide in the presence of a catalytic amount of VO(acac)2 followed by the epoxide ring opening in… read more here.
Keywords: synthesis cytotoxic; isocembrol; hydroxy derivatives; cytotoxic activity ... See more keywords
Synthesis and Cytotoxic Activity of Novel Tetrahydrocurcumin Derivatives Bearing Pyrazole Moiety
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DOI: 10.1007/s13659-017-0143-9
Abstract: Tetrahydrocurcumin (THC) is a major metabolite of curcumin and plays an important role in curcumin-induced biological effects. THC is a promising preventive and chemotherapeutic agent for cancer. A series of new pyrazole derivatives of THC… read more here.
Keywords: tetrahydrocurcumin; cancer; synthesis cytotoxic; cell ... See more keywords
Synthesis and cytotoxic activity of new indolylpyrrole derivatives
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DOI: 10.1016/j.arabjc.2021.103209
Abstract: Abstract The current approach described the synthesis of a new series of indolylpyrrole derivatives through multicomponent reaction of α-cyano chalcones, appropriate aldehydes, and ammonium acetate in refluxed acetic acid. The chemical structures of the designed… read more here.
Keywords: activity new; cytotoxic activity; activity; synthesis cytotoxic ... See more keywords
Design, synthesis and cytotoxic activity of certain novel chalcone analogous compounds.
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DOI: 10.1016/j.ejmech.2016.09.099
Abstract: A series of chalcone analogous compounds were designed and synthesized. Replacing/substituting the enone or ethylenic bridge of the parent chalcone with rigid heterocyclic moieties or substituted aromatic amines gave nineteen target compounds. Their cytotoxic activities… read more here.
Keywords: design synthesis; analogous compounds; chalcone analogous; synthesis cytotoxic ... See more keywords
The synthesis and cytotoxic activity of derivatives of 4β-hydroxywithanolide E
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DOI: 10.1016/j.steroids.2020.108776
Abstract: 4β-hydroxywithanolide E, which can be obtained in large amounts from the Physalis genus, possessed anti-proliferative effects on a variety of human cancer cell lines. For discussing its anti-tumor structure-activity relationship, a series of 4β-hydroxywithanolide E… read more here.
Keywords: activity derivatives; derivatives hydroxywithanolide; synthesis cytotoxic; activity ... See more keywords
Total synthesis and cytotoxic activity of dechlorogreensporones A and D
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DOI: 10.1016/j.tet.2018.07.025
Abstract: Abstract The first and convergent total syntheses of polyketide natural products dechlorogreensporones A and D have been accomplished in 17 longest linear steps with 2.8% and 5.4% overall yields, respectively, starting from known methyl 2-(2-formyl-3,5-dihydroxyphenyl)acetate… read more here.
Keywords: total synthesis; synthesis cytotoxic; synthesis; cytotoxic activity ... See more keywords
Synthesis and Cytotoxic Activity of Lepidilines A-D: Comparison with Some 4,5-Diphenyl Analogues and Related Imidazole-2-thiones.
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DOI: 10.1021/acs.jnatprod.1c00797
Abstract: A straightforward access to 2-unsubstituted imidazole N-oxides with subsequent deoxygenation by treatment with Raney-nickel followed by N-benzylation opens up a convenient route to lepidilines A and C. Both imidazolium salts were used to generate in… read more here.
Keywords: imidazole thiones; diphenyl analogues; synthesis cytotoxic; activity ... See more keywords
First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine
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DOI: 10.1055/s-0036-1588752
Abstract: A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in… read more here.
Keywords: total synthesis; first total; synthesis cytotoxic; aaptamine ... See more keywords
Synthesis and cytotoxic activity of 4-O-β-D-galactopyranosyl derivatives of phenolic acids esters
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DOI: 10.1080/14786419.2017.1375927
Abstract: Abstract The glycosylation of naturally occurring phenolic acids has a significant impact on their solubility, stability and physiochemical properties. D-Galactose residue was found to form a part of glycoconjugates in several tissues and involved in… read more here.
Keywords: cell lines; phenolic acids; cancer cell; synthesis cytotoxic ... See more keywords