Synthesis, cytotoxicity, and molecular docking of substituted 3‐(2‐methylbenzofuran‐3‐yl)‐5‐(phenoxymethyl)‐1,2,4‐oxadiazoles
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DOI: 10.1002/ardp.202000006
Abstract: A series of new benzofuran/oxadiazole hybrids (8a–n) was synthesized from 2H‐chromene‐3‐carbonitriles (3a–c) through the multistep synthetic methodology, and these hybrids are known to exhibit anticancer activities. All the compounds were evaluated for their in vitro… read more here.
Keywords: synthesis cytotoxicity; cytotoxicity molecular; docking substituted; activity ... See more keywords
Synthesis and Cytotoxicity of Octahydroepoxyisoindole‐7‐carboxylic Acids and Norcantharidin–Amide Hybrids as Norcantharidin Analogues
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DOI: 10.1002/cmdc.201900180
Abstract: Octahydroepoxyisoindole analogues of norcantharidin were accessed through a Diels–Alder reaction of an amine‐substituted furan with maleic anhydride and subsequent reduction of the bicyclo[2.2.1]heptene olefin. Despite retention of the carboxylate and the ether bridgehead known to… read more here.
Keywords: norcantharidin analogues; synthesis cytotoxicity; carboxylic acids; cytotoxicity octahydroepoxyisoindole ... See more keywords
Synthesis and Cytotoxicity Evaluation of Pentacyclic Triterpene–Phenol Nitrogen Mustard Conjugates
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DOI: 10.1007/s10600-018-2270-x
Abstract: Using a reported pharmacophore, 4-[N,N-bis(2-chloroethyl)-amino]phenol, and pentacyclic triterpenes, pharmacologically and structurally diverse components of natural products, six pentacyclic triterpene-4-[N,N-bis(2-chloroethyl)-amino]phenol conjugates were synthesized by click chemistry. Their cytotoxicities against the BEL-7404 and NCI-H460 tumor cell lines… read more here.
Keywords: synthesis cytotoxicity; phenol; chemistry; pentacyclic triterpene ... See more keywords
Synthesis and Cytotoxicity of Conjugates of Betulinic Acid and F-Containing 2-Acylcycloalkane-1,3-Diones
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DOI: 10.1007/s10600-018-2565-y
Abstract: Conjugates of betulinic acid with 2-(fluoroacyl)cycloalkane-1,3-dione motifs were synthesized by reacting 3-chloro-2-(fluoroacyl)-2-cycloalkene-1-ones with an equivalent amount of betulinic acid aminoalkylamide hydrochlorides in the presence of Et3N in CHCl3. Reduction of betulonic acid conjugates with 2-trifluoroacetylcyclopentane-1,3-dione… read more here.
Keywords: synthesis cytotoxicity; conjugates betulinic; cytotoxicity conjugates; betulinic acid ... See more keywords
Synthesis and Cytotoxicity of 28-Oxo-Allobetulone Derivatives
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DOI: 10.1007/s10600-020-03064-5
Abstract: 28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by modification of ring A (3- and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone, spiroindole, pyrazole, isoxazole, and tetraoxane derivatives) and 3 β ,19 β ,28-oleantriol were tested… read more here.
Keywords: synthesis cytotoxicity; oxo allobetulone; cytotoxicity oxo; cytotoxicity ... See more keywords
One-pot green synthesis and cytotoxicity of new α-aminophosphonates
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DOI: 10.1007/s11164-017-3060-y
Abstract: A novel series of α-aminophosphonates containing the trifluoromethyl aniline moiety were obtained in high yields by condensation of 2-methyl-3-trifluoromethyl aniline, aryl/heteroaryl aldehydes and dimethylphosphite in the presence of chitosan as a catalyst. The molecular modeling… read more here.
Keywords: synthesis cytotoxicity; pot green; green synthesis; one pot ... See more keywords
Synthesis and cytotoxicity of novel dispiro derivatives of 5-arylidenoxazolones, potential inhibitors of p53—MDM2 protein-protein interaction
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DOI: 10.1007/s11172-018-2111-x
Abstract: Regioselective synthesis of new dispiro indolinones combining both an indolinone and an oxazolone fragment in their structure comprised the 1,3-dipolar cycloaddition of azomethine ylides, generated in situ from isatin and sarcosine, at 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones. When… read more here.
Keywords: protein; synthesis cytotoxicity; cytotoxicity; dispiro derivatives ... See more keywords
Synthesis and cytotoxicity of two novel alcohols based on a benzo[c]phenanthrene moiety
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DOI: 10.1016/j.crci.2018.11.002
Abstract: Abstract Synthetically, 1-(benzo[c]phenanthren-2-yl)ethanol and 1-(benzo[c]phenanthren-2-yl)-3-phenylpropane-1,3-diol were successfully obtained from 2-acetylbenzo[c]phenanthrene and methyl benzo[c]phenanthrene-2-carboxylate, respectively, and fully characterized. The desired compounds were purified by silica gel column chromatography, and their structures were characterized by melting points,… read more here.
Keywords: two novel; cytotoxicity; benzo phenanthrene; synthesis cytotoxicity ... See more keywords
Synthesis, cytotoxicity and antineoplastic activities of novel acridine-based platinum(II) organometallic complexes
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DOI: 10.1016/j.jorganchem.2019.06.024
Abstract: Abstract Two new platinum(II) complexes incorporating acridine ligands with aniline moieties were successfully synthesised and characterised. The acridine-based ligands were synthesised by means of Ullmann's condensation. The reaction of cis -[PtCl 2 (DMSO) 2 ]… read more here.
Keywords: cytotoxicity; acridine based; synthesis cytotoxicity; platinum ... See more keywords
Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers
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DOI: 10.1016/j.mencom.2019.07.004
Abstract: For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of one Ts of them was… read more here.
Keywords: crown ethers; synthesis cytotoxicity; dibenzo diaza; piperidone ... See more keywords
Synthesis and cytotoxicity of novel 14α-O-(andrographolide-3-subsitutedisoxazole-5-carboxylate) derivatives.
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DOI: 10.1080/14786419.2020.1736060
Abstract: Simple and efficient method was established for the synthesis of a new family of 14α-O-(andrographolide-3-subsitutedisoxazole-5-carboxylate) derivatives (10a-j) from naturally occurring andrographolide (1) by selective esterification with propiolic acid at C-14 using protection and deprotection strategy… read more here.
Keywords: synthesis cytotoxicity; subsitutedisoxazole carboxylate; andrographolide subsitutedisoxazole; cytotoxicity ... See more keywords