Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00634
Abstract: The metabolic oxidation of drug-like small molecules by aldehyde oxidase (AO) has commonly been mitigated through the incorporation of deuterium at the oxidation site. We report that dimethylformamide dimethyl acetal and related compounds undergo rapid… read more here.
Keywords: metabolism; aldehyde oxidase; deuterated heterocycles; me2ncd ome ... See more keywords
Synthesis of Deuterated or Tritiated Glycine and Its Methyl Ester
Sign Up to like & getrecommendations! Published in 2018 at "Doklady Chemistry"
DOI: 10.1134/s0012500818110071
Abstract: Heating glycine (Gly) and methyl glycinate (GlyOCH3) supported on 5% Pd/C or 5% Pt/C in a deuterium or tritium gas atmosphere gave the isotope-labeled products. The experiments were carried out at 180°C for 10 min.… read more here.
Keywords: synthesis deuterated; glycine methyl; deuterated tritiated; tritiated glycine ... See more keywords
A practical synthesis of deuterated methylamine and dimethylamine
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Research"
DOI: 10.1177/1747519820969636
Abstract: In recent years, several deuterated drugs have entered clinical trials and have been approved for use. Deuterated methylamine and dimethylamine as important intermediates play significant roles in the preparation of deuterated drugs. In this study,… read more here.
Keywords: methylamine dimethylamine; synthesis deuterated; deuterated drugs; practical synthesis ... See more keywords