Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form
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DOI: 10.1021/acs.jmedchem.3c00428
Abstract: Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible therapy for a range of… read more here.
Keywords: csf1r; selective pyrrolo; synthesis development; autoinhibited form ... See more keywords
Design, Synthesis, and Development of Pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part II—Benzimidazole Derivatives
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DOI: 10.3390/ph15080927
Abstract: Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these proteins in many human cells… read more here.
Keywords: pi3k; design synthesis; pyrazolo pyrimidine; benzimidazole derivatives ... See more keywords
Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I—Indole Derivatives
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DOI: 10.3390/ph15080949
Abstract: Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of this protein causes cellular… read more here.
Keywords: design synthesis; development pyrazolo; pyrazolo pyrimidine; synthesis development ... See more keywords