Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides.
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DOI: 10.1021/jacs.0c07043
Abstract: We report an iodoarene-catalyzed enantioselective synthesis of β,β-difluoroalkyl halide building blocks. The transformation involves an oxidative rearrangement of α-bromostyrenes, utilizing HF-pyridine as the fluoride source and m-CPBA as the stoichiometric oxidant. A catalyst decomposition pathway… read more here.
Keywords: catalytic enantioselective; synthesis difluorinated; difluorinated alkyl; catalyst ... See more keywords