Synthesis of 6,6‐ and 7,7‐Difluoro‐1‐acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO
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DOI: 10.1002/cbic.202200081
Abstract: LolO, a 2‐oxoglutarate‐dependent nonheme Fe oxygenase, catalyzes both the hydroxylation of 1‐exo‐acetamidopyrrolizidine (AcAP), a pathway intermediate in the biosynthesis of the loline alkaloids, and the cycloetherification of the resulting alcohol. We have prepared fluorinated AcAP… read more here.
Keywords: difluoro; nonheme oxygenase; acap; synthesis difluoro ... See more keywords
Synthesis of 2,2-difluoro-3H-benzothiophen-3-ol via a difluorocarbene insertion reaction, investigating the scope for further derivatization
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DOI: 10.1080/00397911.2019.1614629
Abstract: Abstract A simple, and efficient synthesis of 2,2-difluoro-3H-benzothiophen-3-ol using readily available sodium chlorodifluoroacetate (SCDA) is reported. We also explore new chemistry of these difluoro compounds. The salient feature of this approach includes operational simplicity and… read more here.
Keywords: difluoro benzothiophen; benzothiophen via; synthesis difluoro; difluoro ... See more keywords