A Unified Strategy for the Synthesis of Difluoromethyl- and Vinylfluoride-Containing Scaffolds.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02887
Abstract: Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a… read more here.
Keywords: unified strategy; strategy synthesis; difluoromethyl vinylfluoride; synthesis difluoromethyl ... See more keywords
Synthesis of Difluoromethyl-Substituted Quinazolines through Selective Difluoromethylation
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DOI: 10.1055/a-1375-3538
Abstract: A highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield. read more here.
Keywords: synthesis difluoromethyl; difluoromethyl substituted; substituted quinazolines; selective difluoromethylation ... See more keywords