Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-8273-8
Abstract: A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and… read more here.
Keywords: synthesis dihydropyridine; synthesis; calcium channel; papain catalyzed ... See more keywords
Activity of immobilized metallic phthalocyanines in the multicomponent synthesis of dihydropyridine derivatives and their subsequent aromatization
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DOI: 10.1016/j.mcat.2017.03.010
Abstract: Abstract Several supported metallo-sulphonated phthalocyanines (FePcS-NH 2 -SiO 2 , CoPcS-NH 2 -SiO 2 , and CuPcS-NH 2 -SiO 2 ) and iron hexadecachlorinated phthalocyanines (FePcCl 16 -NH 2 -SiO 2 and FePcCl 16 -NH… read more here.
Keywords: metallic phthalocyanines; multicomponent synthesis; immobilized metallic; phthalocyanines multicomponent ... See more keywords
Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines
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DOI: 10.1021/acs.orglett.2c04095
Abstract: The identification of the beneficial pharmacokinetic properties of aza-spirocycles has led to the routine incorporation of these highly rigid and three-dimensional structures in pharmaceuticals. Herein, we report an operationally simple synthesis of spirocyclic dihydropyridines via… read more here.
Keywords: driven dearomatization; dihydropyridine spirocycles; pinacol driven; spirocycles semi ... See more keywords