Modular Synthesis of 2,8-Dioxabicyclo[3.2.1]octanes by Sequential Catalysis
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DOI: 10.1021/acscatal.9b04183
Abstract: A modular synthesis of 2,8-dioxabicyclo[3.2.1]octane (2,8-DOBCO) ketals is realized by sequential catalysis. The key intermediates, e-hydroxyl-β,γ-unsaturated ketones, are readily available by Ni-catalyzed three-component coupling of 1,3-dienes, aldehydes, and acylzirconocene reagents. These polyfunctionalized ketones can undergo… read more here.
Keywords: sequential catalysis; modular synthesis; synthesis dioxabicyclo; catalysis ... See more keywords