Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins.
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DOI: 10.1016/j.bioorg.2020.103835
Abstract: A series ofN-acyl glucosamine-bearingtriterpenoidsaponins has been synthesized with cytotoxic activities evaluated against HL-60, PC-3, HCT-116, and CT-26 tumor cells. Saponins incorporated anoleanolic acid (OA) triterpenoidal core exhibited the highest cytotoxic activity. To study the influence… read more here.
Keywords: analysis mechanism; acyl glucosamine; distribution analysis; mechanism ... See more keywords