Design and Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazole Hybrids Bearing Pyridine and 1,2,3-Triazole Pharmacophores
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DOI: 10.1002/jhet.2672
Abstract: A novel series of 2,5-disubstituted-1,3,4-oxadiazoles decorated with two biodynamic moieties pyridine and 1,2,3-triazole have been successfully synthesized in good yields under mild reaction conditions. The synthesized compounds are valuable for biological activity exploration since three… read more here.
Keywords: design synthesis; hybrids bearing; pyridine triazole; disubstituted oxadiazole ... See more keywords
CuO-Nanoparticles Catalyzed Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Bromoalkenes
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DOI: 10.1007/s12039-018-1452-1
Abstract: A novel and efficient protocol involving commercially available CuO nanoparticles (CNP) as catalyst has been developed for the synthesis of 1,2,3-triazoles. A library of 1,4-disubstituted 1,2,3-triazoles has been constructed with good to excellent yields.Graphical AbstractSynopsisA… read more here.
Keywords: disubstituted triazoles; nanoparticles catalyzed; synthesis disubstituted; cuo nanoparticles ... See more keywords
Zinc oxide nanoparticle promoted highly efficient one pot three-component synthesis of 2,3-disubstituted benzofurans
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2013.06.030
Abstract: Abstract A convenient one-pot synthesis of 2,3-disubstituted benzo[b]furan derivatives has been developed using zinc oxide nanoparticles. The present approach provides a novel, effective and improved procedure for the three-component coupling of aldehydes, secondary amines and… read more here.
Keywords: three component; synthesis disubstituted; zinc oxide; one pot ... See more keywords
Rhodium-catalyzed synthesis of 2,3 – Disubstituted N-methoxy pyrroles and furans via [3+2] cycloaddition between metal carbenoids and activated olefins
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DOI: 10.1016/j.tet.2017.04.007
Abstract: Abstract For the first time, we report the synthesis of 2-substituted N -alkoxy pyrrole 3-carboxylate and furan 3-carboxylate via Rh-catalyzed [3+2] cycloaddition between α-diazo oxime ether or α -diazo carbonyl compounds with vinyl equivalents in… read more here.
Keywords: cycloaddition; rhodium catalyzed; disubstituted methoxy; synthesis disubstituted ... See more keywords
Complementary regioselective synthesis of 3,5-disubstituted isoxazoles from ynones
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DOI: 10.1016/j.tet.2018.09.043
Abstract: Abstract Two regioselective synthetic routes towards 3,5-disubstituted isoxazoles from ynones are reported. One route takes place via first converting the ynones to ynone O-methyl oximes, followed by a palladium-catalyzed intramolecular cyclization. The other involves the… read more here.
Keywords: disubstituted isoxazoles; complementary regioselective; isoxazoles ynones; synthesis disubstituted ... See more keywords
Acid-catalyzed highly diastereoselective and effective synthesis of 1,3-disubstituted tetrahydropyrano[3,4-b]indoles
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DOI: 10.1016/j.tetlet.2016.11.110
Abstract: We successfully explored for the first time that trifluoroacetic acid (TFA) can effectively catalyze the oxaPictet-Spengler reaction of secondary tryptophols and acetals to synthesize 1,3-disubstituted 1,3,4,9-tetrahydropyrano[3,4-b]indoles in high yield (up to >99%) and diastereoselectivity (>20:1).… read more here.
Keywords: tetrahydropyrano; tetrahydropyrano indoles; disubstituted tetrahydropyrano; synthesis disubstituted ... See more keywords
One-pot synthesis of 2,3-disubstituted benzofurans from 2-chlorophenols using palladium–dihydroxyterphenylphosphine catalyst
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DOI: 10.1016/j.tetlet.2018.07.019
Abstract: Abstract 2,3-Disubstituted benzofurans possessing 2-hydroxyphenyl moiety at the C-3 position were synthesized from readily available 2-chlorophenols and terminal alkynes by hydroxy-directed ortho-Sonogashira coupling and subsequent oxypalladation/reductive elimination, using Pd-dihydroxyterphenylphosphine catalyst. The catalyst accelerates not only… read more here.
Keywords: pot synthesis; dihydroxyterphenylphosphine catalyst; synthesis disubstituted; one pot ... See more keywords
Stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via a Beckmann rearrangement facilitated by diphenyl phosphorazidate
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DOI: 10.1016/j.tetlet.2019.04.014
Abstract: Abstract A novel method for the stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via the Beckmann rearrangement was developed using diphenyl phosphorazidate (DPPA) as both the oxime activator and azide source. Various ketoximes were transformed… read more here.
Keywords: tetrazoles ketoximes; disubstituted tetrazoles; stereospecific synthesis; synthesis disubstituted ... See more keywords
Synthesis of 1,1-Disubstituted Indenes and Dihydronaphthalenes through C-C/C-C Bond-Forming Pd-Catalyzed Autotandem Reactions.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01870
Abstract: A novel synthesis of 1,1-disubstituted 1H-indenes is described involving the Pd-catalyzed cascade reaction between o-bromophenyl-β-bromostyrenes and N-tosylhydrazones in a process comprising the consecutive formation of two Csp3-C bonds on the same carbon atom: the cross-coupling… read more here.
Keywords: indenes dihydronaphthalenes; dihydronaphthalenes bond; synthesis disubstituted; bond forming ... See more keywords
Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04946g
Abstract: The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99 : 1 d.r.). read more here.
Keywords: via bronsted; diastereoselective synthesis; isoindolines sultams; sultams via ... See more keywords
Synthesis of 2,3-disubstituted indoles via a tandem reaction
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DOI: 10.1039/d0qo00765j
Abstract: A strategy for the synthesis of 2,3-disubstituted indoles from 2-allyl-2-(2-nitrophenyl)cyclohexane-1,3-dione has been developed. A wide array of 2,3-disubstituted indoles were accessed in modest to good yields via a tandem reduction/condensation/fragmentation/cyclization sequence. The utility of this… read more here.
Keywords: via tandem; tandem reaction; indoles via; synthesis disubstituted ... See more keywords