Synthesis of DNA-Encoded Bicyclic Peptides via Cysteine-Promoted Cyclization and Amide Condensation Reaction.
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.5c00455
Abstract: Bicyclic peptides, with two cyclic substructures, have emerged as a powerful tool for modulating challenging targets such as protein-protein interactions. Meanwhile, DNA-encoded library technology (DELT) provides a powerful platform for hit discovery. The unity of… read more here.
Keywords: synthesis dna; encoded bicyclic; peptides via; bicyclic peptides ... See more keywords
Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc01474e
Abstract: We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible… read more here.
Keywords: phase synthesis; dna encoded; solid phase; synthesis dna ... See more keywords