Synthesis and Docking of Novel 3‐Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5‐HT1AR/SERT
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201600271
Abstract: A series of novel 3‐indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin‐1A receptor subtype (5‐HT1AR) and the 5‐HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the… read more here.
Keywords: ht1ar; synthesis docking; indolylpropyl derivatives; novel indolylpropyl ... See more keywords
Design, synthesis, docking and biological evaluation of chalcones as promising antidiabetic agents.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103527
Abstract: Diabetes mellitus (DM) is a serious chronic metabolic disorder which occurs due to dysfunction of insulin and therapeutic approaches are poor. It is an under estimation that 387 million people currently suffering globally with diabetic… read more here.
Keywords: design synthesis; synthesis docking; biological evaluation; evaluation chalcones ... See more keywords
Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.010
Abstract: A novel series of dihydro-1,3,5-triazine derivatives bearing a heteroatom spiro-ring were designed and synthesized on the basis of molecular flexible docking work, and their biological activities were evaluated. Compounds A2, A5, B1 and B3 showed… read more here.
Keywords: novel; design synthesis; dihydro; synthesis docking ... See more keywords
Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.012
Abstract: In this study, a series of benzimidazoles bearing thiosemicarbazide chain or triazole and thiadiazole rings were designed and synthesized. Crystal and molecular structure of the compound 5c has been characterized by single crystal X-ray crystallographic… read more here.
Keywords: design synthesis; synthesis docking; docking studies; studies benzimidazole ... See more keywords
Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86424-7
Abstract: A novel series of substituted 4,6-dimethyl-2-oxo-1-(thiazol-2-ylamino)-1,2-dihydropyridine-3-carbonitrile derivatives 6, 9, 13, 15, and 17 was synthesized in a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)thiourea with 2-oxo-N'-arylpropanehydrazonoyl chloride, chloroacetone, α-bromoketones, ethyl chloroacetate, and 2,3-dichloroquinoxaline,… read more here.
Keywords: design synthesis; studies novel; synthesis docking; docking studies ... See more keywords
Synthesis, Docking and Anticancer Evaluation of New Pyridine-3-Carbonitrile Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2020.1870507
Abstract: N'-(2-((4-(Benzo[d][1, 3]dioxol-5-yl)-3-cyano-6-(naphthalen-2-yl)-pyridin-2-yl)oxy)- acetyl)benzohydrazide (6) and hydrazide derivatives (7–10) were synthesized via reaction of 3-cyano-pyridinaceto... read more here.
Keywords: anticancer evaluation; pyridine carbonitrile; docking anticancer; synthesis docking ... See more keywords
Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2175209
Abstract: Abstract New thiazolopyrimidine derivatives 2, 3a-d, 4a-c, 5, 6a-c, and 7a,b were synthesised. All prepared compounds were evaluated by MTT cytotoxicity assay against three human tumour cell lines. Compounds 3c, 3d, 4c, 6a, 6b, and… read more here.
Keywords: design synthesis; synthesis docking; evaluations new; docking anticancer ... See more keywords
New approach for the synthesis, docking of new porphyrins and their antitumor activity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s1088424619500093
Abstract: A new methodology for the synthesis of a new series of mesotetrakis[aryl]-21H,23H-porphyrin derivatives 5a–5d, 6a–6c, 7 and 8 is presented. Structures of new compounds were established based on both elemental and spectral data. Cytotoxicity activity… read more here.
Keywords: synthesis; docking new; new approach; activity ... See more keywords
Synthesis, docking studies, biological activity of carbon monoxide release molecules based on coumarin derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.996079
Abstract: In the present work, we synthesized seven complexes. All complexes were identified by ESI-HRMS, 1H-NMR, 19F-NMR and 13C-NMR spectroscopies. The synthesized complexes were tested for their anticancer activities in vitro against three different human cell… read more here.
Keywords: docking studies; synthesis docking; biological activity; complex could ... See more keywords