An Approach to the Synthesis of Electron-Rich and Hindered Esters and Its Application to the Synthesis of Acteoside.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03528
Abstract: Electron-rich esters are ubiquitously distributed in natural products and play a central role in bioactivities. Herein, we disclose an efficient, mild, and general esterification approach to the synthesis of these esters by employing gold(I)-catalyzed acylation… read more here.
Keywords: electron rich; synthesis acteoside; synthesis electron; approach synthesis ... See more keywords
Synthesis of Electron-Deficient Heteroaromatic 1,3-Substituted Cyclobutyls via Zinc Insertion/Negishi Coupling Sequence under Batch and Automated Flow Conditions.
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DOI: 10.1021/acs.orglett.8b03588
Abstract: Synthesis of 1,3-substituted cyclobutyls enabled by zinc insertion into functionalized iodocyclobutyl derivatives followed by Negishi coupling with halo-heteroaromatics is reported. Two distinct sets of conditions were developed; the first involved a two-step batch protocol using… read more here.
Keywords: substituted cyclobutyls; zinc insertion; synthesis electron; negishi coupling ... See more keywords
Electrochemical Organic Synthesis of Electron-Rich Biaryl Scaffolds: An Update
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DOI: 10.3390/molecules26226968
Abstract: Biaryl scaffolds are widely spread in biologically important natural products, in numerous therapeutic agents, but they are also considered a privileged class of ligands and (organo)catalysts; therefore, the development of efficient alternative methodologies to prepare… read more here.
Keywords: biaryl; electron rich; electrochemical organic; organic synthesis ... See more keywords