Stereodivergent Synthesis of Enantioenriched α-Deuterated α-Amino Acids via Cascade Cu(I)-Catalyzed H-D Exchange and Dual Cu- and Ir-Catalyzed Allylation.
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DOI: 10.1021/acs.orglett.2c02102
Abstract: A one-pot Cu-mediated H-D exchange with inexpensive heavy water as the deuterium source, followed by Cu- and Ir-catalyzed stereodivergent allylic alkylation, has been developed, providing efficient access to enantioenriched α-deuterium-labeled α-amino acids from readily available… read more here.
Keywords: amino acids; deuterated amino; enantioenriched deuterated; exchange ... See more keywords
Asymmetric Synthesis of Enantioenriched Zigzag-Type Molecular Belts by Kinetic Resolution and Subsequent Transformations.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01314
Abstract: Asymmetric synthesis of enantioenriched zigzag-type molecular belts featuring copper/H8-binaphthol-catalyzed kinetic resolution of a resorcinarene derivative and subsequent transformations was developed. The acquired rigid and C4-symmetric belt exhibited remarkably enhanced photophysical and chiroptical properties in comparison… read more here.
Keywords: zigzag type; molecular belts; type molecular; enantioenriched zigzag ... See more keywords
The Fluoro-Pauson-Khand Reaction in the Synthesis of Enantioenriched Nitrogenated Bicycles Bearing a Quaternary C-F Stereogenic Center.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02557
Abstract: A variety of enantioenriched fluorinated 6H-cyclopenta[c]pyridin-6-one bicycles, a scaffold present in several classes of monoterpenic alkaloids with varied biological activity, were synthesized in just five steps from simple aldehyde starting materials. The synthesis presented wide… read more here.
Keywords: reaction synthesis; synthesis enantioenriched; fluoro pauson; pauson khand ... See more keywords
Synthesis of Enantioenriched Bromohydrins via Divergent Reactions of Racemic Intermediates from Anchimeric Oxygen Borrowing.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b06432
Abstract: We report a chiral phosphoric acid catalyzed bromocyclization/regiodivergent reaction of racemic intermediates sequence, which is enabled by anchimeric oxygen borrowing. Different types of alkenes are applicable, and both enantiomers of the bromohydrin products were obtained… read more here.
Keywords: racemic intermediates; synthesis enantioenriched; oxygen borrowing; anchimeric oxygen ... See more keywords
Organocatalytic synthesis of enantioenriched 1,2,4-triazolines containing a chiral quaternary carbon center
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DOI: 10.1039/c6ra28800f
Abstract: An efficient asymmetric cyclization reaction of amino-acid-derived isothiocyanates with azodicarboxylates is described. The chiral 1,2,4-triazolines are prepared in good yield (up to 87%) and enantioselectivities (up to 95% ee). read more here.
Keywords: containing chiral; synthesis enantioenriched; enantioenriched triazolines; triazolines containing ... See more keywords
Synthesis of enantioenriched α-heteroatom functionalised aldehydes by chiral organocatalysis and their synthetic applications
Sign Up to like & getrecommendations! Published in 2021 at "Organic Chemistry Frontiers"
DOI: 10.1039/d1qo00101a
Abstract: Asymmetric organocatalysis is a versatile method for the enantioselective α-functionalisation of aldehydes. The synthetic scope for chiral α-heteroatom substituted aldehydes is examined including their applications in synthesis. read more here.
Keywords: organocatalysis; synthesis enantioenriched; enantioenriched heteroatom; heteroatom ... See more keywords