Enzyme‐Catalyzed Efficient Synthesis of Enantiomerically Pure (S)‐ and (R)‐n‐Butylphthalide
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DOI: 10.1002/cbic.202500482
Abstract: 3‐n‐Butylphthalide (NBP) is an effective commercial drug for the treatment of acute ischemic stroke, with its S‐enantiomer, (S)‐NBP, demonstrating clinical superiority over (R)‐NBP. However, the stereoselective synthesis of both enantiomers with high enantiomeric excess (ee)… read more here.
Keywords: enantiomerically pure; catalyzed efficient; synthesis; enzyme catalyzed ... See more keywords
Synthesis of Enantiomerically Pure Pyrimidine Ribonucleosides Locked in the South Conformation.
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DOI: 10.1021/acs.orglett.2c03853
Abstract: The conformation of the central five-membered ring of a nucleoside plays an important role in enzyme recognition. Bicyclo[3.1.0]hexane, also known as the methanocarba (MC), serves as a template that can mimic the locked forms of… read more here.
Keywords: pyrimidine ribonucleosides; conformation; synthesis enantiomerically; pure pyrimidine ... See more keywords