A convenient synthesis of enantiopure (4aS,7aR)-1,4,4a,7a-tetrahydrocyclopenta[c]pyran-3,7-dione
Sign Up to like & getrecommendations! Published in 2020 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2020.01.003
Abstract: The title compound, as the new chiral building block for bioactive cyclopentenones, was prepared in 8 steps with 15% overall yield. The key steps involve selective homologation in intermediate [(1S,2R,5R)-5-trimethysilylcyclopent-3-ene- 1,2-diyl]dimethanol by regioselective silylation followed… read more here.
Keywords: 7ar tetrahydrocyclopenta; convenient synthesis; enantiopure 4as; synthesis enantiopure ... See more keywords
A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c01547
Abstract: Propargylic alcohols and amines are versatile building blocks in organic synthesis. We demonstrate a straightforward enzymatic cascade to synthesize enantiomerically pure propargylic alcohols and amines from readily available racemic starting materials. In the first step,… read more here.
Keywords: synthesis enantiopure; alcohols amines; propargylic alcohols; platform synthesis ... See more keywords
Practical synthesis of enantiopure benzylamines by catalytic hydrogenation or transfer hydrogenation reactions in isopropanol using a Ru-pybox catalyst
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00908a
Abstract: The screening of a family of complexes of the formula [RuCl2(R-pybox)(L)] (R-pybox = Ph-, iPr- or indane-pybox; L = monodentate P, N or C ligand) in the enantioselective hydrogenation of N-aryl imines indicates a strong… read more here.
Keywords: hydrogenation; practical synthesis; transfer hydrogenation; pybox ... See more keywords