A Short Synthesis of Ergot Alkaloids and Evaluation of the 5-HT1/2 Receptor Selectivity of Lysergols and Isolysergols.
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DOI: 10.1021/acs.orglett.2c02569
Abstract: Key transformations in a four-step synthesis of the ergot alkaloid scaffold include a novel cesium carbonate-mediated hydrogen autotransfer alkylation to generate the C(3)-C(4) bond and an intramolecular Heck reaction that directly establishes the C(9)-C(10) alkene… read more here.
Keywords: short synthesis; ergot alkaloids; synthesis; alkaloids evaluation ... See more keywords