Site-Selective Synthesis of C-17 Ester Derivatives of Natural Andrographolide for Evaluation as a Potential Anticancer Agent
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00036
Abstract: A library of 57 compounds of natural andrographolide was designed, synthesized, and screened for in vitro studies against four human cancer cell lines: A594, PC-3, MCF-7, and HCT-116. Most of the synthesized compounds displayed better… read more here.
Keywords: natural andrographolide; cell; site selective; synthesis ester ... See more keywords
Synthesis of the ester side chains of homoharringtonine and harringtonine using lactones as building blocks
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DOI: 10.1080/00397911.2020.1829643
Abstract: Abstract The efficient synthesis of the ester side chains of homoharringtonine and harringtonine using lactones as building blocks has been developed. The synthesis used classic reactions from readily available starting materials. Reactions of the lactone… read more here.
Keywords: side chains; chains homoharringtonine; ester side; harringtonine using ... See more keywords
Chemo-enzymatic Synthesis of Ester-Linked Docetaxel-Glycoside Conjugate and its Drug Delivery System Using Hybrid-Bio-Nanocapsules Targeted With Trastuzumab and Cetuximab
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Communications"
DOI: 10.1177/1934578x19858803
Abstract: Synthesis of ester-linked glucoside conjugate of docetaxel, 7-propionyldocetaxel 3''-O-α-D-glucopyranoside, was carried out by chemo-enzymatic procedures. The EE and LE values for hybrid-bio-nanocapsules of 7-propionyldocetaxel 3''-O-α-D-glucopyranoside were much improved rather than those of docetaxel. The hybrid-bio-nanocapsules… read more here.
Keywords: chemo enzymatic; bio nanocapsules; ester linked; nanocapsules targeted ... See more keywords