Synthesis of Functionalized δ‐Hydroxy‐β‐keto Esters and Evaluation of Their Anti‐inflammatory Properties
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200073
Abstract: δ‐Hydroxy‐β‐keto esters and δ,β‐dihydroxy esters are characteristic structural motifs of statin‐type natural products and drug candidates. Here, we describe the synthesis of functionalized δ‐hydroxy‐β‐keto esters in good yields and excellent enantioselectivities using Chan's diene and… read more here.
Keywords: synthesis functionalized; functionalized hydroxy; hydroxy keto; keto esters ... See more keywords
2D‐2D Nanocomposite of MoS2‐Graphitic Carbon Nitride as Multifunctional Catalyst for Sustainable Synthesis of C3‐Functionalized Indoles
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DOI: 10.1002/cctc.201800369
Abstract: A nanocomposite of two‐dimensional MoS2 supported on graphitic C3N4 nanosheets has been prepared by a facile ultrasonication method followed by demonstrating its ability to catalyze the synthesis of several indole derivatives. The as‐prepared nanocomposite catalyst… read more here.
Keywords: functionalized indoles; synthesis functionalized; nanocomposite mos2; catalyst ... See more keywords
Synthesis of Functionalized Quinolines from 4-(o-Nitroaryl)-Substituted 3-Acyl-4,5-Dihydrofurans: Reductive Cyclization and C=C Bond Cleavage
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700256
Abstract: A new synthetic approach to functionalized quinolines was developed based on the application of Zn–AcOH system as a simple and efficient reductive agent towards 4-(o-nitroaryl)-3-acyl-substituted 4,5-dihydrofurans. Reduction of 3-carbonyl-substituted dihydrofurans is accomplished by C=C double-bond… read more here.
Keywords: synthesis functionalized; functionalized quinolines; cyclization; bond cleavage ... See more keywords
Cp2Fe‐Mediated Electrochemical Synthesis of Functionalized Compounds: Recent Advances
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400021
Abstract: Unlike traditional organic methods, electrosynthesis has emerged as an environmentally friendly and sustainable approach to generate a series of functionalized compounds. In this process, the traceless electron serves as the redox agent, eliminating the need… read more here.
Keywords: functionalized compounds; compounds recent; synthesis functionalized; mediated electrochemical ... See more keywords
Synthesis of Functionalized 2‐Hydrazono‐3‐thiazolines from 2‐Substituted Oxazoles through a One‐Pot Multicomponent/Rearrangement Process
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400940
Abstract: The serendipitous rearrangement of an oxazole nucleus to a thiazoline ring under mild conditions is described. This transformation was achieved by a multicomponent reaction (MCR) featuring 2‐(bromomethyl)oxazoles, thiosemicarbazide, and a carbonyl compound to provide oxazole‐derived… read more here.
Keywords: rearrangement; hydrazono thiazolines; synthesis functionalized; one pot ... See more keywords
Synthesis of Functionalized Cyclooctynes as Building Blocks for Non‐covalent Surface‐Orthogonal Chemistry
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500124
Abstract: Cyclooctynes substituted with functional groups capable for hydrogen bonding (amide, imide, carboxylic acid) have been synthesized. The 8‐membered ring was derived from cyclooctadiene, by Beckmann rearrangement or by ring‐closing metathesis. The transannular instability of a… read more here.
Keywords: chemistry; functionalized cyclooctynes; surface orthogonal; synthesis functionalized ... See more keywords
A Mild and Efficient Synthesis of Functionalized 2‐Fluorobenzamides from 1,2,3‐Benzotriazinones via Denitrogenative Fluorination Reactions under Thermal/Visible Light Conditions
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500375
Abstract: An efficient method for the synthesis of 2‐fluorobenzamides was established from 1,2,3‐benzotriazinones using tetrafluoroboric acid. The reactions proceeded under mild thermal conditions, providing a wide range of functionalized 2‐fluorobenzamides in 65‐80% yields. On the other… read more here.
Keywords: functionalized fluorobenzamides; mild efficient; visible light; synthesis functionalized ... See more keywords
An Efficient and Facile Synthesis of Functionalized Indole-3-yl Pyrazole Derivatives Starting from 3-Cyanoacetylindole
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DOI: 10.1002/jhet.2654
Abstract: The versatile hitherto reported 3-(1H-indol-3-yl)-1H-pyrazol-5-amine () was synthesized by the reaction of 3-cyanoacetylindole () with hydrazine hydrate in refluxing ethanol and used as a key intermediate for the synthesis of novel pyrazolo[1,5-a]pyrimidines via its reactions… read more here.
Keywords: pyrazole; synthesis functionalized; facile synthesis; functionalized indole ... See more keywords
ONE-POT DIASTEREOSELECTIVE SYNTHESIS OF FUNCTIONALIZED 4,5-DIHYDROPYRROLES BY REACTIONS OF ARYLGLYOXALS, β-DICARBONYL COMPOUNDS, AND AROMATIC AMINES
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5055
Abstract: A multicomponent reaction of arylglyoxal hydrates, acetylacetone or acetoacetic ester, aniline or its 3(4)-substituted analogs in 1:1:2 ratio occurred upon stirring in methanol, giving 4-arylamino-5-hydroxypyrroline derivatives containing 4,5-dihydroxypyrrolines as impurities. read more here.
Keywords: diastereoselective synthesis; synthesis functionalized; functionalized dihydropyrroles; dihydropyrroles reactions ... See more keywords
SYNTHESIS OF FUNCTIONALIZED OXAZOLIDINES BY MULTICOMPONENT REACTIONS OF 1,2-AMINO ALCOHOLS
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5439
Abstract: Recent (2011–2019) multicomponent syntheses of functionalized oxazolidines using 1,2-amino alcohols as starting materials are reviewed. The synthetic strategies are gathered into three groups: metal-free domino annulation/Mannich reactions, transition metal-catalyzed cascade reactions, extended one-pot asymmetric azaelectrocyclization. read more here.
Keywords: multicomponent reactions; functionalized oxazolidines; synthesis functionalized; reactions amino ... See more keywords
Simple and efficient route for the synthesis of functionalized 2,3,7,8-tetrahydro-4H,6H-pyrano[3,2-g]chromene-4,6-diones
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-017-2085-x
Abstract: A novel series of spiro[chromene-2,1'-cyclohexan]-4(3H)-one derivatives containing either a chalcone or flavanone fragment in their molecules was synthesized. 2'-Hydroxychalcones, containing a spirochromanone moiety, underwent cyclocondensation with formation of a condensed pyran ring. The catalytic efficiency… read more here.
Keywords: route synthesis; chromene; synthesis functionalized; efficient route ... See more keywords