Synthesis of fusidane triterpenoid Mannich bases as potential antibacterial and antitumor agents.
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DOI: 10.1080/14786419.2022.2163483
Abstract: Mannich bases (8 examples) were synthesized via aminomethylation of fusidane propargyl esters. In vitro antimicrobial screening against key ESKAPE pathogens showed that the fusidic acid based Mannich products exhibit a high antimicrobial effect against Gram-positive… read more here.
Keywords: fusidane; fusidane triterpenoid; synthesis fusidane; mannich bases ... See more keywords