A New Synthesis of Gefitinib
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DOI: 10.1055/s-0037-1610375
Abstract: A four-step synthesis of the FDA-approved anticancer agent gefitinib was developed starting from 2,4-dichloro-6,7-dimethoxyquinazoline. Reaction temperatures were highly practical (0–55 °C), and chromatographic purifications were avoided. The ionic liquid trimethylammonium heptachlorodialuminate was used to monodemethylate the… read more here.
Keywords: new synthesis; synthesis gefitinib; synthesis;