A one-step synthesis of gem-difluoroolefins from alcohols
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2020.109649
Abstract: Abstract The development of efficient protocols for the synthesis of gem-difluoroolefins has received increasing attention. Given the ubiquity of hydroxyl group in biologically active molecules and synthetic intermediates, we developed a one-step protocol for the… read more here.
Keywords: step synthesis; gem difluoroolefins; gem; synthesis gem ... See more keywords
An efficient method for the synthesis of gem-difluoroolefins
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DOI: 10.1016/j.tetlet.2016.12.070
Abstract: A series of gem-difluoroolefin derivatives were synthesized in moderate to good yields by the reaction of α,α-difluoro-β-carbonyl benzothiazol-2-yl sulfones (DFBTs) with various carbon nucleophiles. Using dl-proline as organocatalyst, the reaction of DFBT with acetone gave… read more here.
Keywords: efficient method; gem; gem difluoroolefins; synthesis gem ... See more keywords
Synthesis of gem-Difluorinated 1,3-Dienes via Synergistic Cu/Pd-Catalyzed Borodifluorovinylation of Alkynes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01875
Abstract: gem-Difluoroalkenes (=CF2), which normally act as metabolically stable bioisosteres for carbonyl groups (C═O), are widely applied in agrochemicals and pharmaceuticals and are also used as building blocks in organic synthesis. Herein, an example of Cu/Pd-catalyzed… read more here.
Keywords: gem difluorinated; gem; catalyzed borodifluorovinylation; difluorinated dienes ... See more keywords
Organophotocatalysis Enables the Synthesis of gem-Fluorophosphonate Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03366
Abstract: gem-Bromofluoroalkenes have been combined with phosphite under irradiation, in the presence of Fukuzumi's catalyst (9-mesityl-10-methylacridinium perchlorate) as an organic photocatalyst, to provide valuable gem-fluorophosphonate derivatives, known as stable mimics of phosphates. The desired products were… read more here.
Keywords: gem; enables synthesis; gem fluorophosphonate; organophotocatalysis enables ... See more keywords
Alkyltriflones in the Ramberg-Bäcklund Reaction: An Efficient and Modular Synthesis of gem-Difluoroalkenes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c07924
Abstract: The unprecedented synthesis of gem-difluoroalkenes through the Ramberg-Bäcklund reaction of alkyl triflones is described herein. Structurally diverse, fully-substituted gem-difluoroalkenes that are difficult to prepare by other methods can be easily prepared from readily available triflones… read more here.
Keywords: gem; gem difluoroalkenes; cklund reaction; synthesis gem ... See more keywords
Enantioselective synthesis of gem-disubstituted N-Boc diazaheterocycles via decarboxylative asymmetric allylic alkylation† †Electronic supplementary information (ESI) available: Experimental procedures, 1H NMR, 13C NMR, and IR spectra. See DOI: 10.1039/c8sc03967d
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc03967d
Abstract: An enantioselective synthesis of diverse N4-Boc-protected α,α-disubstituted piperazin-2-ones and tetrahydropyrimidin-2-ones using the palladiumcatalyzed decarboxylative allylic alkylation reaction has been achieved. read more here.
Keywords: gem disubstituted; synthesis gem; allylic alkylation; enantioselective synthesis ... See more keywords
Metal-free synthesis of gem-difluorinated heterocycles from enaminones and difluorocarbene precursors.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00383j
Abstract: A cascade strategy to synthesise gem-difluorinated 2H-furans from reactions of BrCF2CO2Et with enaminones has been described. The reactions tolerate a wide variety of functional groups under metal-free conditions. An active aminocyclopropane is proposed to be… read more here.
Keywords: gem difluorinated; gem; metal free; free synthesis ... See more keywords