Acid-promoted oxidative methylenation of 1,3-dicarbonyl compounds with DMSO: application to the three-component synthesis of Hantzsch-type pyridines
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DOI: 10.1039/c7ra07442e
Abstract: A highly convergent one-pot synthesis of Hantzsch-type pyridines has been developed based on a three-component annulation of 1,3-dicarbonyl compounds, DMSO, and ammonium salt. A transition-metal-free oxidative methylenation reaction/Hantzsch pyridine synthesis cascade reaction was involved in… read more here.
Keywords: hantzsch type; dicarbonyl compounds; synthesis; synthesis hantzsch ... See more keywords
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives
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DOI: 10.3390/ijms21207652
Abstract: We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca+2 channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl… read more here.
Keywords: cholinesterases calcium; synthesis hantzsch; hantzsch adducts; flux inhibitors ... See more keywords