Articles with "synthesis hdac" as a keyword



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Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids

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Published in 2022 at "Beilstein Journal of Organic Chemistry"

DOI: 10.3762/bjoc.18.84

Abstract: Histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through the deacetylation of nuclear histone and non-histone proteins and are promising therapeutic targets for the treatment of various diseases. Here, the… read more here.

Keywords: based hydroxamic; synthesis hdac; group; pyrimidine based ... See more keywords