Synthesis of 4-hetero-16α,17α-cyclohexanopregnanes and evaluation of their cytotoxicity against the HeLa cell line
Sign Up to like & getrecommendations! Published in 2018 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-018-2336-8
Abstract: The oxidation of the ring A of 16α,17α-cyclohexanoprogesterone gave 5-oxo-A-nor-3,5-secopregnan-3-oic acid. The subsequent ring A closure in the latter compound upon treatment with sodium acetate in Ac2O afforded 4-oxasteroid. The reaction with ammonium acetate in… read more here.
Keywords: evaluation cytotoxicity; cytotoxicity hela; cyclohexanopregnanes evaluation; synthesis hetero ... See more keywords
Enantioselective synthesis of hetero-triarylmethanes by chiral phosphoric acid-catalyzed 1,4-addition of 3-substituted indoles with azadienes
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DOI: 10.1016/j.tetlet.2021.152862
Abstract: Abstract An efficient catalytic enantioselective 1,4-addition reaction of 3-substituted indoles, pyrroles and furans with substitution of azadienes by a chrial phosphoric acid was developed. A large variety of C2 substituted triarylmethanes derivatives were achieved in… read more here.
Keywords: substituted indoles; phosphoric acid; addition; enantioselective synthesis ... See more keywords
Synthesis and hetero-Diels-Alder reactions of enantiomerically pure dihydro-1H-azepines.
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DOI: 10.1039/d0cc04413j
Abstract: Thermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes in the presence of K2CO3 gives in good yields 2-alkyl-6-halo-1-tosyl-2,3-dihydro-1H-azepines. These undergo highly stereoselective [4+2] cycloaddition reactions with heterodienophiles and arylation/alkenylation under Suzuki conditions. read more here.
Keywords: diels alder; dihydro azepines; hetero diels; synthesis hetero ... See more keywords
Recent advances in the synthesis of 5-(hetero)aryl uracil derivatives
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DOI: 10.1055/a-2091-1071
Abstract: C5-Aryl/heteroaryl uracil-based compounds have attracted continuous interest because of their wide biological potential. In this review we outlined the primary synthetic methods used to prepare designated uracils, all of which were often combined to synthesize… read more here.
Keywords: hetero aryl; hetero; aryl; synthesis hetero ... See more keywords