The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1→4GlcNAcβ1→3Galβ1→4Glc).
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate research"
DOI: 10.1016/j.carres.2019.107743
Abstract: The discovery of innovative methods that offer new capabilities for obtaining individual oligosaccharides from human milk will help to improve understanding their roles and boost practical applications. The total chemical synthesis of lacto-N-neotetraose (LNnT) has… read more here.
Keywords: synthesis human; human milk; chemical synthesis; lacto neotetraose ... See more keywords
Synthesis of a Human Urinary Metabolite of Prostaglandin D2.
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DOI: 10.1021/acs.orglett.9b03983
Abstract: A chemical synthesis of the major human metabolite of prostaglandin D2, tricyclic-PGDM, is described. The synthetic route starts from iodocyclopentenone 1 (available from cyclopentadiene in 6 steps) and requires 13 synthetic transformations. The synthetic route… read more here.
Keywords: metabolite prostaglandin; synthesis human; human urinary; metabolite ... See more keywords
Microbial Synthesis of Human-Hormone Melatonin at Gram Scales.
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DOI: 10.1021/acssynbio.0c00065
Abstract: Melatonin is a commercially attractive tryptophan-derived hormone. Here we describe a bioprocess for the production of melatonin using Escherichia coli to high titers. The first engineered strain produced 0.13 g/L of melatonin from tryptophan under… read more here.
Keywords: synthesis human; microbial synthesis; human hormone; tryptophan ... See more keywords
Synthesis, human topoisomerase IIα inhibitory properties and molecular modeling studies of anti-proliferative curcumin mimics
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DOI: 10.1039/c9ra05661k
Abstract: Piperidinecarboxamides (curcumin mimics) show promising anti-proliferative properties against HCT116 (colon), MCF7 (breast) and A431 (squamous skin) carcinoma cell lines with potency higher than that of 5-fluorouracil. read more here.
Keywords: human topoisomerase; anti proliferative; synthesis human; topoisomerase inhibitory ... See more keywords