The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1→4GlcNAcβ1→3Galβ1→4Glc).
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate research"
DOI: 10.1016/j.carres.2019.107743
Abstract: The discovery of innovative methods that offer new capabilities for obtaining individual oligosaccharides from human milk will help to improve understanding their roles and boost practical applications. The total chemical synthesis of lacto-N-neotetraose (LNnT) has… read more here.
Keywords: synthesis human; human milk; chemical synthesis; lacto neotetraose ... See more keywords
Synthesis of a Human Urinary Metabolite of Prostaglandin D2.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03983
Abstract: A chemical synthesis of the major human metabolite of prostaglandin D2, tricyclic-PGDM, is described. The synthetic route starts from iodocyclopentenone 1 (available from cyclopentadiene in 6 steps) and requires 13 synthetic transformations. The synthetic route… read more here.
Keywords: metabolite prostaglandin; synthesis human; human urinary; metabolite ... See more keywords
Microbial Synthesis of Human-Hormone Melatonin at Gram Scales.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.0c00065
Abstract: Melatonin is a commercially attractive tryptophan-derived hormone. Here we describe a bioprocess for the production of melatonin using Escherichia coli to high titers. The first engineered strain produced 0.13 g/L of melatonin from tryptophan under… read more here.
Keywords: synthesis human; microbial synthesis; human hormone; tryptophan ... See more keywords
Synthesis, human topoisomerase IIα inhibitory properties and molecular modeling studies of anti-proliferative curcumin mimics
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DOI: 10.1039/c9ra05661k
Abstract: Piperidinecarboxamides (curcumin mimics) show promising anti-proliferative properties against HCT116 (colon), MCF7 (breast) and A431 (squamous skin) carcinoma cell lines with potency higher than that of 5-fluorouracil. read more here.
Keywords: human topoisomerase; anti proliferative; synthesis human; topoisomerase inhibitory ... See more keywords
Mangiferin, a component of Mangifera indica leaf extracts, inhibits lipid synthesis in human sebocytes
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2024.2369279
Abstract: Abstract Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of Mangifera indica leaves… read more here.
Keywords: human sebocytes; mangifera indica; synthesis; lipid synthesis ... See more keywords
Synergistic impact of antioxidant combinations on collagen and elastin synthesis in human dermal fibroblasts
Sign Up to like & getrecommendations! Published in 2025 at "Bio-Medical Materials and Engineering"
DOI: 10.1177/09592989251341159
Abstract: Background: The restoration of collagen and elastin in human dermal fibroblasts plays a crucial role in anti-aging and skin rejuvenation therapies. Numerous studies have examined the effects of various antioxidants on skin health, but there… read more here.
Keywords: collagen elastin; elastin synthesis; dermal fibroblasts; synthesis human ... See more keywords