Synthesis of 5‐ and 7‐hydroxy indolizidin‐2‐one prostaglandin‐F2α modulators and activity on myometrial contractility towards development of agents for delaying preterm birth
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3455
Abstract: In pursuit of more effective‐labor delaying tocolytic agents, the prostaglandin F2α (PGF2α) receptor (FP) modulator PDC113.824 [(6S)‐2] represents a potent lead for developing therapy to treat preterm birth. Derivatives of FP modulator (6S)‐2 were synthesized,… read more here.
Keywords: preterm birth; hydroxy indolizidin; prostaglandin modulators; indolizidin one ... See more keywords
An efficient and rapid synthesis of 3-hydroxy-3-alkyl-2-oxindoles via Zn-mediated barbier-type reaction under aqueous conditions
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DOI: 10.1007/s12039-017-1329-8
Abstract: Abstract A robust and rapid synthesis of 3-hydroxy-3-alkyl-2-oxindoles from isatins is described. This method introduces an ecofriendly, un-activated Zn dust, solid $$\hbox {NH}_{4}\hbox {Cl}$$NH4Cl and substrates under aqueous conditions, which has produced the product in moderate… read more here.
Keywords: alkyl oxindoles; rapid synthesis; aqueous conditions; synthesis hydroxy ... See more keywords
CoFe2O4/Cu(OH)2 magnetic nanocomposite: an efficient and reusable heterogeneous catalyst for one-pot synthesis of β-hydroxy-1,4-disubstituted-1,2,3-triazoles from epoxides
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DOI: 10.1039/c9ra06038c
Abstract: Magnetically separable CoFe2O4/Cu(OH)2 nanocomposite was prepared and used as a novel heterogeneous catalyst for synthesis of β-hydroxy-1,4-disubstituted-1,2,3-triazoles from epoxides. read more here.
Keywords: disubstituted triazoles; hydroxy disubstituted; triazoles epoxides; synthesis hydroxy ... See more keywords
Synthesis of 7-hydroxy-6H-naphtho[2,3-c]coumarin via a TsOH-mediated tandem reaction.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc04452k
Abstract: A concise and efficient method for the synthesis of 7-hydroxy-6H-naphtho[2,3-c]coumarin using available 1-(2-hydroxyphenyl)-2-phenylethanone and Meldrum's acid has been developed. This transformation involved a tandem aldol reaction/lactonization/Friedel-Crafts reaction to form a lactone ring and a benzene… read more here.
Keywords: naphtho coumarin; tandem reaction; synthesis hydroxy; reaction ... See more keywords
Synthesis of 4-hydroxy-5-methyl-2-[2-(4-oxo-4H-chromen-3-yl)ethenyl]-6H-1,3-oxazin-6-ones and their reaction with hydrazine
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217050103
Abstract: Abstract4-Hydroxy-6H-1,3-oxazin-6-ones containing a 3-vinylchromone fragment in the 2-position were synthesized. The direction of their reactions with hydrazine hydrate was found to depend on the solvent nature. The reaction in protic solvents (methanol, acetic acid) resulted… read more here.
Keywords: oxazin ones; hydroxy methyl; hydrazine; hydroxy ... See more keywords
Synthesis of hydroxy-α-sanshool
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DOI: 10.1177/1747519820974323
Abstract: Hydroxy-α-sanshool was synthesized in a 13% overall yield through eight steps, which included two Wittig reactions that were used to form the carbon skeleton with ethyl 2-oxoacetate and 2E,4E-hexadienal being reacted with the appropriate ylides.… read more here.
Keywords: hydroxy sanshool; synthesis hydroxy; sanshool; ethyl ... See more keywords
One-step Synthesis of 2-Hydroxy-2-(trifluoromethyl)malonates by Trifluoromethylation of 2-Oxomalonates with Ruppert-Prakash Reagent
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DOI: 10.1246/cl.190942
Abstract: The one-step synthesis of 2-hydroxy-2-(trifluoromethyl)malonates is described. The nucleophilic trifluoromethylation of commercially available 2-oxo-malonates was possible by use of the Ruppert-Pra... read more here.
Keywords: trifluoromethyl malonates; step synthesis; synthesis hydroxy; one step ... See more keywords
Regioselective One-Pot Synthesis of Hydroxy-(S)-Equols Using Isoflavonoid Reductases and Monooxygenases and Evaluation of the Hydroxyequol Derivatives as Selective Estrogen Receptor Modulators and Antioxidants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.830712
Abstract: Several regiospecific enantiomers of hydroxy-(S)-equol (HE) were enzymatically synthesized from daidzein and genistein using consecutive reduction (four daidzein-to-equol–converting reductases) and oxidation (4-hydroxyphenylacetate 3-monooxygenase, HpaBC). Despite the natural occurrence of several HEs, most of them had… read more here.
Keywords: regioselective one; pot; one pot; pot synthesis ... See more keywords