Synthesis of 19-hydroxyprogesterone and insights into the ring-opening mechanism of the 6,19-epoxy bridge.
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DOI: 10.1080/10286020.2022.2144260
Abstract: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature (11.0% total yield). The plausible… read more here.
Keywords: ring opening; synthesis hydroxyprogesterone; opening mechanism; mechanism epoxy ... See more keywords