Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179688
Abstract: The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying formaldehyde and piperidine, but a second paraformaldehyde molecule was incorporated… read more here.
Keywords: synthesis hydroxyquinolines; synthesis; hydroxyquinolines potential; cytotoxic agents ... See more keywords