Isolation, synthesis, identification of new process-related impurities in evocalcet.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2022.114715
Abstract: Evocalcet is a calcimimetic for the treatment of secondary hyperparathyroidism. In the preparation of evocalcet, eleven process-related impurities were detected in the reaction solution of the last step at levels of 0.05%- 2.50% by a new… read more here.
Keywords: identification new; related impurities; isolation synthesis; synthesis identification ... See more keywords
Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.02.077
Abstract: Abstract Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the synthesis and identification of one… read more here.
Keywords: synthesis identification; hydroxyl group; adamantyl ring; metabolite akb ... See more keywords
Design, synthesis and identification of novel molecular hybrids based on naphthoquinone aromatic hydrazides as potential trypanocide and leishmanicidal agents.
Sign Up to like & getrecommendations! Published in 2024 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202420230375
Abstract: In pursuit of potential agents to treat Chagas disease and leishmaniasis, we report the design, synthesis, and identification novel naphthoquinone hydrazide-based molecular hybrids. The compounds were subjected to in vitro trypanocide and leishmanicidal activities. N'-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)-3,5-dimethoxybenzohydrazide… read more here.
Keywords: identification novel; molecular hybrids; synthesis identification; design synthesis ... See more keywords