Atroposelective synthesis of isoquinolinone bearing two distinct C-N axes via cobalt-catalyzed enantioselective C-H activation/annulation.
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DOI: 10.1039/d5cc05883j
Abstract: We report a Co/Salox-catalyzed atroposelective C-H activation/annulation process that concurrently constructs dual C-N stereogenic axes under mild conditions. By incorporating acyclic axial chirality into 1,3-biaxial scaffolds, we achieve diverse multi-axial chiral architectures, thereby expanding the… read more here.
Keywords: atroposelective synthesis; activation annulation; synthesis isoquinolinone; activation ... See more keywords