An Asymmetric Synthesis of (+)-Isostrychnine Based on Catalytic Asymmetric Tandem Double Michael Addition.
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DOI: 10.1021/acs.orglett.1c01828
Abstract: Herein, a concise asymmetric synthesis of (+)-isostrychnine is achieved in nine longest-linear steps with a 16% overall yield. The key features of this synthesis include the catalytic asymmetric tandem double Michael addition of a tryptamine-derived… read more here.
Keywords: tandem double; asymmetric tandem; synthesis isostrychnine; double michael ... See more keywords