Synthesis of jaspine B regioisomers through palladium-catalyzed stereoselective tetrahydrofuran formation: Insight into the ligand recognition of sphingosine kinases
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DOI: 10.1016/j.tet.2018.02.042
Abstract: Abstract We recently reported a structure-activity relationship study of 4-epi-jaspine B derivatives toward sphingosine kinase (SphK) and identified selective inhibitors of two SphK isoforms. In this study, we designed and synthesized jaspine B regioisomers on… read more here.
Keywords: tetrahydrofuran formation; palladium catalyzed; jaspine; jaspine regioisomers ... See more keywords