Synthesis of α-ketoamides using potassium superoxide (KO2) as an oxidizing agent
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DOI: 10.1016/j.tet.2020.131262
Abstract: Abstract A simple and convenient method for the synthesis of α-ketoamides by the oxidation of aryl acetamides using potassium superoxide (KO2) as an oxidizing agent is disclosed here. The scope of the developed method is… read more here.
Keywords: superoxide ko2; ko2 oxidizing; potassium superoxide; oxidizing agent ... See more keywords
Selective cleaving the N P bond of difluoromethylene phosphabetaines for effective synthesis of β-ketoamides
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DOI: 10.1016/j.tetlet.2019.06.036
Abstract: Abstract An unprecedent transition-metal-free protocol for the synthesis of β-ketoamides from β-ketoesters is described. This method involves selective cleaving N P bond of an unusual aminating reagent, [tris(dimethylamino)phosphonio]difluoroacetate (ADFA), which is well known as the… read more here.
Keywords: cleaving bond; synthesis ketoamides; selective cleaving; difluoromethylene ... See more keywords
Synthesis of α-Ketoamides via Gold(I) Carbene Intermediates.
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DOI: 10.1021/acs.orglett.2c01489
Abstract: α-Ketoamides have been found to be an important functional group in a broad spectrum of inhibitors such as the Corona virus and other viruses. Here we report an unprecedented gold-catalyzed 2-fold reaction of a bromoalkyne… read more here.
Keywords: carbene intermediates; synthesis ketoamides; ketoamides via; gold carbene ... See more keywords