Convenient Synthesis of C ‐Linked β ‐D‐Galactosides with Lipophilic Aglycone Component Toward Lectin A Inhibition and Antibiofilm Properties
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DOI: 10.1002/ejoc.202500826
Abstract: Pseudomonas aeruginosa , a member of the World Health Organization‐listed ESKAPE pathogens, exhibits high drug resistance and relies on the galactose‐specific lectin LecA for adhesion, biofilm formation, and virulence. Targeting lectin A (LecA) emerges as… read more here.
Keywords: galactosides lipophilic; synthesis linked; synthesis; linked galactosides ... See more keywords
Stereoselective Synthesis of N-O-Linked α-N-Acetylgalactosaminoglycosides via Oxime O-Glycosylation with 2-Nitrogalactals.
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DOI: 10.1021/acs.orglett.5c03416
Abstract: GalNAc-type O-glycosylation is an essential post-translational modification that plays fundamental roles in various biological processes. N-O-linked glycosidic linkages are desirable and practical mimetics of native O-glycosidic bonds. However, efficient construction of α-aminooxy GalNAc linkages remains… read more here.
Keywords: oxime glycosylation; synthesis linked; linked acetylgalactosaminoglycosides; acetylgalactosaminoglycosides via ... See more keywords
Catalytic Method for the Synthesis of C-N-Linked Bi(heteroaryl)s Using Heteroaryl Ethers and N-Benzoyl Heteroarenes.
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DOI: 10.1021/acs.orglett.8b00245
Abstract: C-N-linked bi(heteroaryl)s are synthesized by a rhodium-catalyzed N-heteroarylation reaction of N-benzoyl heteroarenes including azoles/azolones, pyridones, cyclic ureas, and cyclic imides using heteroaryl aryl ethers. The reaction involves the covalent bond-exchange reaction of N-CO and HetAr-O… read more here.
Keywords: linked heteroaryl; catalytic method; synthesis linked; using heteroaryl ... See more keywords