Synthesis of Lipidated Ligands and Formulation of Glia-Specific LNPs for RNAi-Mediated BBB Protection.
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DOI: 10.1021/acs.jmedchem.4c01176
Abstract: Pro-inflammatory polarization of microglia and astrocytes results in neuroinflammation and blood-brain barrier (BBB) disruption after a primary traumatic brain injury (TBI). Herein, we demonstrate that the dual-ligand functionalized lipid nanoparticles (AM31 LNPs) were actively and… read more here.
Keywords: lipidated ligands; synthesis lipidated; ligands formulation; microglia astrocytes ... See more keywords